From a94b494dc02c8e22ccb4cd257e2f6d1c8a7aef81 Mon Sep 17 00:00:00 2001 From: "lorenzo.zolfanelli93" Date: Thu, 6 Aug 2020 23:35:15 +0000 Subject: [PATCH] Update on Overleaf. --- chapters/1-introduction.tex | 48 +- images/tj.pdf | Bin 0 -> 49108 bytes images_src/tj.svg | 1118 +++++++++++++++++++++++++++++++++++ 3 files changed, 1162 insertions(+), 4 deletions(-) create mode 100644 images/tj.pdf create mode 100644 images_src/tj.svg diff --git a/chapters/1-introduction.tex b/chapters/1-introduction.tex index 163d735..15daf09 100644 --- a/chapters/1-introduction.tex +++ b/chapters/1-introduction.tex @@ -189,18 +189,58 @@ Lo stato attuale delle conoscenze sulla rete di interazioni che governa e regola il funzionamento delle giunzioni aderenti è riportato in Appendice, sotto forma di diagramma delle vie di segnalazione. +\begin{figure} + \centering + \includegraphics{images/aj.pdf} + \caption{Ruolo di \textbf{caderina} e catenine nelle \textit{giunzioni aderenti}} + \label{fig:aj} +\end{figure} + \vspace{1em} Un'altra classe di giunzioni cellulari è rappresentata dalle giunzioni occludenti (\textit{tight junction}), la cui caratteristica principale è quella di sigillare lo spazio intercellulare, rendendolo -impermeabile +impermeabile e impedendo a molecole e ioni di attraversare un +tessuto. +L'organizzazione spaziale delle giunzioni occludenti consente inoltre +la creazione di canali selettivamente permeabili per il trasporto +di specifiche molecole, tuttavia ancora non sono chiari i meccanismi +che modulano e regolano il loro funzionamento. +Come nel caso delle giunzioni aderenti questo emerge dall'interazione +tra un certo numero di proteine interagenti. + \begin{figure} \centering - \includegraphics{images/aj.pdf} - \caption{Ruolo di \textbf{caderina} e catenine nelle \textit{giunzioni aderenti}} - \label{fig:my_label} + \includegraphics{images/tj.pdf} + \caption{Ruolo di \textbf{ZO-1} nelle \emph{giunzioni occludenti}} + \label{fig:tj} \end{figure} +Diverse proteine attraversano la membrana e dimerizzano +con le loro omologhe appartenenti alla cellula adiacente, +tra le quali \emph{claudina}, \emph{occludina} e diverse +proteine appartenenti alla classe delle \textit{junctional +adhesion molecules}, (JAM). +Queste proteine di membrana si legano alla proteina \textit{Zona occludens 1}, ZO-1 che, come mostrato da +recenti studi \cite{??}, potrebbe modulare la formazione +delle giunzioni e occuparsi della trasduzione di segnali +meccanici. +Inoltre vi sono evidenze sul ruolo di una terza proteina, +la \textit{cingulina}, nel modulare l'interazione di ZO-1 +con il citoscheletro di actina. Un'ipotesi è che il +legame cingulina-ZO-1 possa indurre delle modifiche +conformazionali in ZO-1 tali da consentire un legame +diretto con in filamenti di actina. +Anche in questo caso, per comprendere il ruolo della cingulina +nella trasduzione dei segnali meccanici, sembra promettente +utilizzare una tecnica che consenta, durante l'osservazione +dell'interazione di due proteine sottoposte a stress +meccanici, di osservare l'eventuale attaccamento al complesso +di una terza proteina. 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