diff --git a/CHANGELOG_PENDING.md b/CHANGELOG_PENDING.md
index e06bf4c06..099e6fcf0 100644
--- a/CHANGELOG_PENDING.md
+++ b/CHANGELOG_PENDING.md
@@ -27,6 +27,7 @@ Special thanks to external contributors on this release:
 
 - Go API
 
+  - [rpc] \#7474 Remove the "URI" RPC client. (@creachadair)
   - [libs/pubsub] \#7451 Internalize the pubsub packages. (@creachadair)
   - [libs/sync] \#7450 Internalize and remove the library. (@creachadair)
   - [libs/async] \#7449 Move library to internal. (@creachadair)
diff --git a/rpc/jsonrpc/client/args_test.go b/rpc/jsonrpc/client/args_test.go
deleted file mode 100644
index 2506f3073..000000000
--- a/rpc/jsonrpc/client/args_test.go
+++ /dev/null
@@ -1,39 +0,0 @@
-package client
-
-import (
-	"testing"
-
-	"github.com/stretchr/testify/assert"
-	"github.com/stretchr/testify/require"
-)
-
-type Tx []byte
-
-type Foo struct {
-	Bar int
-	Baz string
-}
-
-func TestArgToJSON(t *testing.T) {
-	assert := assert.New(t)
-	require := require.New(t)
-
-	cases := []struct {
-		input    interface{}
-		expected string
-	}{
-		{[]byte("1234"), "0x31323334"},
-		{Tx("654"), "0x363534"},
-		{Foo{7, "hello"}, `{"Bar":"7","Baz":"hello"}`},
-	}
-
-	for i, tc := range cases {
-		args := map[string]interface{}{"data": tc.input}
-		err := argsToJSON(args)
-		require.Nil(err, "%d: %+v", i, err)
-		require.Equal(1, len(args), "%d", i)
-		data, ok := args["data"].(string)
-		require.True(ok, "%d: %#v", i, args["data"])
-		assert.Equal(tc.expected, data, "%d", i)
-	}
-}
diff --git a/rpc/jsonrpc/client/encode.go b/rpc/jsonrpc/client/encode.go
deleted file mode 100644
index e085f51a2..000000000
--- a/rpc/jsonrpc/client/encode.go
+++ /dev/null
@@ -1,46 +0,0 @@
-package client
-
-import (
-	"fmt"
-	"net/url"
-	"reflect"
-
-	tmjson "github.com/tendermint/tendermint/libs/json"
-)
-
-func argsToURLValues(args map[string]interface{}) (url.Values, error) {
-	values := make(url.Values)
-	if len(args) == 0 {
-		return values, nil
-	}
-
-	err := argsToJSON(args)
-	if err != nil {
-		return nil, err
-	}
-
-	for key, val := range args {
-		values.Set(key, val.(string))
-	}
-
-	return values, nil
-}
-
-func argsToJSON(args map[string]interface{}) error {
-	for k, v := range args {
-		rt := reflect.TypeOf(v)
-		isByteSlice := rt.Kind() == reflect.Slice && rt.Elem().Kind() == reflect.Uint8
-		if isByteSlice {
-			bytes := reflect.ValueOf(v).Bytes()
-			args[k] = fmt.Sprintf("0x%X", bytes)
-			continue
-		}
-
-		data, err := tmjson.Marshal(v)
-		if err != nil {
-			return err
-		}
-		args[k] = string(data)
-	}
-	return nil
-}
diff --git a/rpc/jsonrpc/client/http_uri_client.go b/rpc/jsonrpc/client/http_uri_client.go
deleted file mode 100644
index 061622942..000000000
--- a/rpc/jsonrpc/client/http_uri_client.go
+++ /dev/null
@@ -1,85 +0,0 @@
-package client
-
-import (
-	"context"
-	"fmt"
-	"io"
-	"net/http"
-	"strings"
-
-	rpctypes "github.com/tendermint/tendermint/rpc/jsonrpc/types"
-)
-
-const (
-	// URIClientRequestID in a request ID used by URIClient
-	URIClientRequestID = rpctypes.JSONRPCIntID(-1)
-)
-
-// URIClient is a JSON-RPC client, which sends POST form HTTP requests to the
-// remote server.
-//
-// URIClient is safe for concurrent use by multiple goroutines.
-type URIClient struct {
-	address string
-	client  *http.Client
-}
-
-var _ HTTPClient = (*URIClient)(nil)
-
-// NewURI returns a new client.
-// An error is returned on invalid remote.
-// The function panics when remote is nil.
-func NewURI(remote string) (*URIClient, error) {
-	parsedURL, err := newParsedURL(remote)
-	if err != nil {
-		return nil, err
-	}
-
-	httpClient, err := DefaultHTTPClient(remote)
-	if err != nil {
-		return nil, err
-	}
-
-	parsedURL.SetDefaultSchemeHTTP()
-
-	uriClient := &URIClient{
-		address: parsedURL.GetTrimmedURL(),
-		client:  httpClient,
-	}
-
-	return uriClient, nil
-}
-
-// Call issues a POST form HTTP request.
-func (c *URIClient) Call(ctx context.Context, method string,
-	params map[string]interface{}, result interface{}) (interface{}, error) {
-
-	values, err := argsToURLValues(params)
-	if err != nil {
-		return nil, fmt.Errorf("failed to encode params: %w", err)
-	}
-
-	req, err := http.NewRequestWithContext(
-		ctx,
-		http.MethodPost,
-		c.address+"/"+method,
-		strings.NewReader(values.Encode()),
-	)
-	if err != nil {
-		return nil, fmt.Errorf("new request: %w", err)
-	}
-	req.Header.Set("Content-Type", "application/x-www-form-urlencoded")
-
-	resp, err := c.client.Do(req)
-	if err != nil {
-		return nil, fmt.Errorf("post: %w", err)
-	}
-	defer resp.Body.Close()
-
-	responseBytes, err := io.ReadAll(resp.Body)
-	if err != nil {
-		return nil, fmt.Errorf("read response body: %w", err)
-	}
-
-	return unmarshalResponseBytes(responseBytes, URIClientRequestID, result)
-}
diff --git a/rpc/jsonrpc/jsonrpc_test.go b/rpc/jsonrpc/jsonrpc_test.go
index 3426c48b8..626959b01 100644
--- a/rpc/jsonrpc/jsonrpc_test.go
+++ b/rpc/jsonrpc/jsonrpc_test.go
@@ -273,11 +273,6 @@ func TestServersAndClientsBasic(t *testing.T) {
 			ctx, cancel := context.WithCancel(bctx)
 			defer cancel()
 
-			cl1, err := client.NewURI(addr)
-			require.Nil(t, err)
-			fmt.Printf("=== testing server on %s using URI client", addr)
-			testWithHTTPClient(ctx, t, cl1)
-
 			cl2, err := client.New(addr)
 			require.Nil(t, err)
 			fmt.Printf("=== testing server on %s using JSONRPC client", addr)
@@ -295,31 +290,6 @@ func TestServersAndClientsBasic(t *testing.T) {
 	}
 }
 
-func TestHexStringArg(t *testing.T) {
-	ctx, cancel := context.WithCancel(context.Background())
-	defer cancel()
-
-	cl, err := client.NewURI(tcpAddr)
-	require.Nil(t, err)
-	// should NOT be handled as hex
-	val := "0xabc"
-	got, err := echoViaHTTP(ctx, cl, val)
-	require.Nil(t, err)
-	assert.Equal(t, got, val)
-}
-
-func TestQuotedStringArg(t *testing.T) {
-	ctx, cancel := context.WithCancel(context.Background())
-	defer cancel()
-	cl, err := client.NewURI(tcpAddr)
-	require.Nil(t, err)
-	// should NOT be unquoted
-	val := "\"abc\""
-	got, err := echoViaHTTP(ctx, cl, val)
-	require.Nil(t, err)
-	assert.Equal(t, got, val)
-}
-
 func TestWSNewWSRPCFunc(t *testing.T) {
 	ctx, cancel := context.WithCancel(context.Background())
 	defer cancel()