--- a/src/dsp/dsp.h
+++ b/src/dsp/dsp.h
@@ -128,7 +128,7 @@ extern "C" {
 #define WEBP_HAVE_NEON
 #endif
 
-#if defined(__mips__) && !defined(__mips64) && \
+#if defined(__mips__) && !defined(__mips16) && !defined(__mips64) && \
     defined(__mips_isa_rev) && (__mips_isa_rev >= 1) && (__mips_isa_rev < 6)
 #define WEBP_USE_MIPS32
 #if (__mips_isa_rev >= 2)